Background: This study examined the refractive and visual outcome of wavefront-optimized laser in situ keratomileusis\r\n(LASIK) in eyes with low myopia and compound myopic astigmatism = 0.75 diopter (D).\r\nMethods: 153 eyes from 153 consecutive myopic patients (74 male, 79 female; mean age at surgery 40.4 �± 10.4 years)\r\nwho had a preoperative refractive cylinder = 0.75 D and a manifest sphere between -0.25 D and -2.75 D, and who had\r\ncompleted 4-month follow-up. Three subgroups defined by the magnitude of preoperative manifest refractive cylinder\r\n(0.25, 0.50, and 0.75 D) were formed. Manifest refraction, uncorrected and corrected visual acuity were assessed pre- and\r\npostoperatively. The astigmatic changes achieved were determined using the Alpins vector analysis.\r\nResults: After 4 months (120.0 �± 27.6 days) of follow-up, a mean uncorrected distant visual acuity of 0.07 �± 0.11 logMAR\r\nand a mean manifest refraction spherical equivalent of -0.06 �± 0.56 D were found. There was no statistically significant\r\ndifference in efficacy and safety between the preoperative cylinder groups. Astigmatic overcorrection for preoperative\r\ncylinder of = 0.50 D was suggested by the correction index, the magnitude of error, the index of success, and\r\nthe flattening index.\r\nConclusions: Low myopic eyes with a preoperative cylinder of = 0.50 D were significantly overcorrected with\r\nregard to cylinder correction when combined with low myopic LASIK. Accordingly, we are cautious in\r\nrecommending full astigmatic correction for eyes with low myopia and manifest cylinder of = 0.50 D.
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